國立台灣大學分子與細胞生物學研究所博士 (2006/07)

馬偕醫學院 生物醫學研究所 專任助理教授2018/8-2022/1
馬偕醫學院 生物醫學研究所 博士後研究員 2015/8~2018/7
台灣大學 分子與細胞生物學研究所 博士後研究員 2013/8~2015/7
台灣大學 分子與細胞生物學研究所 助理研究學者 2011/8~2013/7
台灣大學 分子與細胞生物學研究所 博士後研究員 2006/10~2011/7

馬偕醫學院 生物醫學研究所 專任副教授 2022/2~

1. 分子生物
2. 發育生物學
3. 基因轉殖

1. 肌肉功能
2. 神經退化
3. 小分子核糖核酸
4. 人類疾病模式動物（魚）

1. Lee HJ, Chao HT, Lee YH, Lin CY, Tsai HJ.  The Upstream 1350~1250 Nucleotide Sequences of the Human ENDOU-1 Gene Contain Critical Cis-Elements Responsible for Upregulating Its Transcription during ER Stress. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Vol.24-No.24:e17393. Dec. 2023. (SCI/SCIE)
2. Fu CY, Chen HY, Lin CY, Chen SJ, Sheu JC, Tsai HJ.  Extracellular Pgk1 interacts neural membrane protein enolase-2 to improve the neurite outgrowth of motor neurons. Communications Biology. Vol.6-No.1:e849. Aug. 2023. (SCI/SCIE)
3. Lee HC, Lai WL, Lin CY, Zeng CW, Sheu JC, Chou TB, Tsai HJ.  Anp32a promotes neuronal regeneration after spinal cord injury of zebrafish embryos. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Vol.23-No.24:e15921. Dec. 2022. (SCI/SCIE)
4. Lin CY, Lin HY,  Chuang CK, Zhang PH, Tu YR, Lin SP, Tsai HJ.  Quantification of Idua enzymatic activity combined with observation of phenotypic change in zebrafish embryos provide a preliminary assessment of mutated idua correlated with mucopolysaccharidosis type I. Journal of Personalized Medicine. Vol.12-No.8:e1199. Jul. 2022. (SCI/SCIE)
5. Lee BJ, Tsai JC, Hung CW, Lin CY, Sheu JC, Tsai HJ.  High antimicrobial activity of lactoferricin-expressing Bacillus subtilis strains. Microbial biotechnology. Vol.15-No.6:1895-1909. Jun. 2022. (SCI/SCIE)
6. Lin CY, Tseng HC, Chu YR, Wu CL, Zhang PH, Tsai HJ.  Cerebroventricular Injection of Pgk1 Attenuates MPTP-Induced Neuronal Toxicity in Dopaminergic Cells in Zebrafish Brain in a Glycolysis-Independent Manner. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. Vol.23:e4150. Apr. 2022. (SCI/SCIE)
7. Lee HJ, Lin CY, Tsai HJ.  Zebrafish, an in vivo platform to screen drugs and proteins for biomedical use. Pharmaceuticals. Vol.14-No.6:e500-e500. May. 2021. (SCI/SCIE)
8. Lee BC, Tsai JC, Lin CY, Hung CW, Sheu JC, Tsai HJ.  Using Bacillus subtilis as a host cell to express an antimicrobial peptide from the marine chordate ciona intestinalis. Marine Drugs. Vol.19-No.2:e111. Feb. 2021. (SCI/SCIE)
9. Lee HC, Fu CY, Lin CY, Hu JR, Huang TY, Lo KY, Tsai HY, Sheu JC, Tsai HJ.  Poly(U)-specific endoribonuclease ENDOU promotes translation of human CHOP mRNA by releasing uORF element-mediated inhibition. EMBO JOURNAL. Vol.40-No.11:e104123-e104147. Jan. 2021. (SCI/SCIE)
10. Lin CY, Lin HY, Chung CK, Zhang PH, Tu RY, Lin SP, Tsai HJ.  Effect of Mutated ids Overexpression on IDS Enzyme Activity and Developmental Phenotypes in Zebrafish Embryos: A Valuable Index for Assessing Critical Point-Mutations Associated with Mucopolysaccharidosis Type II Occurrence in Humans. Diagnostics. Vol.10:854-854. Oct. 2020. (SCI/SCIE)
11. Lee BC, Hung CW, Lin CY, Shih CH, Tsai HJ.  Oral administration of transgenic biosafe microorganism containing antimicrobial peptide enhances the survival of tilapia fry infected bacterial pathogen.. FISH & SHELLFISH IMMUNOLOGY. Vol.95:606-616. Dec. 2019. (SCI/SCIE)
12. Yang CY, Chen C, Lin CY, Chen YH, Lin CY, Chi CW, Chen YJ, Liu SC, Chang TK, Tang CH, Lai YW, Tsai HJ, Chen JJ, Wang SW.  Garcimultiflorone K inhibits angiogenesis through Akt/eNOS- and mTORdependent pathways in human endothelial progenitor cells.. PHYTOMEDICINE. Vol.64:52911-52911. Nov. 2019. (SCI/SCIE)
13. Lin CY, Wu CL, Lee KZ, Chen YJ, Zhang PH, Chang CY, Harn HJ, Lin SZ,  Tsai HJ.  Extracellular Pgk1 enhances neurite outgrowth of motoneurons through Nogo66/NgR-independent targeting of NogoA. eLife. Vol.8:1-22. Jul. 2019. (SCI/SCIE)
14. Chang HY, Ko TP, Chang YC, Huang KF, Lin CY, Chou HY, Chiang CY, Tsai HJ.  Crystal structure of the blue fluorescent protein with a Leu-Leu-Gly tri-peptide chromophore derived from the purple chromoprotein of Stichodactyla haddoni. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. Vol.130:675-684. Jun. 2019. (SCI/SCIE)
15. Lin CY, Zhang PH, Chen YJ, Wu CL, Tsai HJ.  Conditional overexpression of rtn4al in muscle of adult zebrafish displays defects similar to human amyotrophic lateral sclerosis. MARINE BIOTECHNOLOGY. Vol.21:52-64. Feb. 2019. (SCI/SCIE)
16. Lin CY, Lee HC, Wu JH, Tsai HJ.  Short fish-origin DNA elements served as flanking sequences in a knockdown cloning vector enabling the generation of a functional siRNA molecule in mammalian cells and fish embryos. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol.505:850-857. Nov. 2018. (SCI/SCIE)
17. Lin CY, He JY, Loo MR, Chang WY, Zeng CW, Tsai HJ.  microRNA-206 mediates boundary formation in newly forming somites through an Rtn4a/Cxcr4a/Thbs3a pathway. Open Biology. Vol.7:70009-70016. Jul. 2017. (SCI)
18. Chiang CY#, Lin CY#, Chen YT#, Tsai HJ.  Blue fluorescent protein derived from the mutated purple chromoprotein isolated from the sea anemone stichodactyla haddoni. Protein Engineering Design & Selection. Vol.11:523-530. Nov. 2016. (SCI)
19. Lin CY, Chiang CY, Tsai HJ.  Zebrafish and Medaka: new model organisms for modern biomedical research. Journal of Biomedical Science. Vol.23:19-29. Jan. 2016. (SCI)
20. Lin CY, Huang HY, Lu PN, Lin CW, Lu KM, Tsai HJ.  Ras-related nuclear protein is required for late developmental stages of retinal cells in zebrafish eyes. The International journal of developmental biology. Vol.59:435-442. Oct. 2015. (SCI)
21. Lin CY, Lee HC, Chen HC, Hsieh CC, Tsai HJ.  Normal function of Myf5 during gastrulation is required for pharyngeal arch cartilage development in zebrafish embryos. Zebrafish. Vol.10:486-499. Dec. 2013. (SCI)
22. Chung HY, Kuo WC, Cheng YH, Yu CH, Chia SH, Lin CY, Chen JS, Tsai HJ, Fedotov AB, Ivanov AA, Zheltikov AM, Sun CK.  Blu-ray disk lens as the objective of a miniaturized two-photon fluorescence microscope. Optics Express. Vol.21:31604-31614. Dec. 2013. (SCI)
23. Lin CY, Lee HJ, Fu CY, Ding YY, Chen JC, Lee MH, Huang WJ, Tsai HJ.  miR-1 and miR-206 target different genes to have opposing roles during angiogenesis in zebrafish embryos. Nature communications. Vol.4:2829-2839. Nov. 2013. (SCI)
24. Lin CY, Chen JS, Loo MR, Hsiao CC, Chang WY, Tsai HJ.  MicroRNA-3906 regulates fast muscle differentiation through modulating the target gene homer-1b in zebrafish embryos. PLoS One. Vol.8:70187-70205. Jul. 2013. (SCI)

1. Lin CY, Wu CL, Lee KZ, Chen YJ, Zhang PH, Chang CY, Harn HJ, Lin SZ, Tsai HJ.  Reduced secretion of Pgk1 from NogoA-overexpressed muscle cells inhibits neurite outgrowth of motoneurons. The 14th International Zebrafish Conference. Jun. 2019.
2. Lin CY*。  Using Zebrafish as an Animal Model to Study on Neurodegenerative Diseases. 進階老人分子醫學與長期照護國際研討會. 12月 2018.

cylin@mmc.edu.tw